#4471 CHARACTERISTICS OF PATIENTS WITH CKD WHO USE HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS: A JAPAN MEDICAL DATA CENTER DATABASE STUDY

Abstract Background and Aims Anemia is common among patients with chronic kidney disease (CKD) reported to be associated increased cardiovascular all-cause mortality, as well reduced quality of life. The incidence anemia increases function declines affects approximately 32% Japanese stage 3–5 CKD [1]. Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have been approved in the Japan since Sept 2019 for disease. Available HIF-PHIs include roxadustat (approved 2019), daprodustat June 2020), vadadustat enarodustat 2020) molidustat Jan 2021). This analysis aims provide a real-world account patient characteristics those initiating approval Japan, overall by individual treatments. Method retrospective cohort study leveraged data from Medical Data Center (JMDC) database Nov 2018 – May 2022 included over 18 years age documented who initiated any HIF-PHI 2021. JMDC health insurance aggregating administrative claims data, medical examination ledger information are on employer-based <75 age. index date was defined first observed claim during identification period. Patients were required baseline period 1 year prior minimum six months follow-up after date, continuous enrollment. assessed demographics, clinical characteristics, previous treatment Results Overall, 500 HIF-PHIs, 47.8% (n = 239) daprodustat, 40.8% 204) roxadustat, 11.4% 57) other HIF-PHIs. Table illustrates demographic HIF-PHI. 60.2% 301) male; mean 55.7 (SD 10.8). More than third (37.2%) received dialysis Within 184 specified types dialysis, 67.9% 125) had hemodialysis 32.1% 59) peritoneal dialysis. In terms treatments, 61.8% 309) rhEPO use Further break down 2. Nearly (31.6%, n 158) iron period, 19.2% 96) receiving oral 13.8% 69) injectable iron. At baseline, almost all comorbidities hypertension (95.8%; 479) diabetes (77.0%; 385). Conclusion Evaluating within allows more comprehensive picture characteristics. Our found most male, use, history diabetes. Understanding profiles setting may guide decisions practice.